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Medical Jane

Last updated: June 1st, 2016

Tetrahydrocannabivarin (THCV) is an antagonist of the CB1 and CB2 receptors. It is being studied for its use as an appetite suppressant and has many other potential medicinal applications. THCV is much more psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger.

THCV is a minor cannabinoid found in only some strains of cannabis. The only structural difference between THCV and THC is the presence of a propyl (3 carbon) group, rather than a pentyl (5 carbon) group, on the molecule. Though this variation may seem subtle, it causes THCV to produce very different effects than THC. These effects include a reduction in panic attacks, suppression of appetite, and the promotion of bone growth.

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