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Medical Jane

Last updated: June 1st, 2016

The concept of the “entourage effect” was introduced in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam. The theory is that cannabinoids within the cannabis plant work together through a network of coincidental relationships as part of a greater organism, and affect the body in a mechanism similar to the body’s own endocannabinoid system. Basically, these compounds work better together than in isolation.

When delivered in high concentrations, THC can cause overdosing. Although an acute THC overdose rarely requires medical intervention, the side effects can be very unpleasant. Good evidence shows that THC and CBD work together. CBD is known to lock out THC at the CB1 receptor. Therefore, applying the entourage effect, increasing CBD in the case of an overdose may lessen the effects of THC.

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