Browsing Cannabinoid Science

Tetrahydrocannabivarin (THCV) is an antagonist of the CB1 and CB2 receptors. It is being studied for its use as an appetite suppressant and has many other potential medicinal applications. THCV is much more psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger. THCV is a minor cannabinoid found in only some strains of cannabis. The only structural difference between THCV and THC is the presence of a propyl (3 carbon) group, rather than …

Cannabidiol (CBD) is a cannabinoid found in medical marijuana that has tremendous medical potential. This is particularly true when the correct ratio of CBD to THC is applied to treat a particular condition. CBD acts as an antagonist at both the CB1 and CB2 receptors, yet it has a low binding affinity for both. This suggests that CBD’s mechanism of action is mediated by other receptors in the brain and body. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = …

Cannabidiolic Acid (CBDA) is an active component found in the cannabis plant that offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers. CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA). Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …

Cannabigerol (CBG) is a non-psychoactive cannabinoid with antibacterial effects that can alter the overall effects of cannabis. CBG is known to kill or slow bacterial growth, reduce inflammation (particularly in its acidic CBGA form), inhibit cell growth in tumor/cancer cells, and promote bone growth. It acts as a low-affinity antagonist at the CB1 receptor. CBG pharmacological activity at the CB2 receptor is currently unknown. Additionally, CBG works with the other cannabinoids in medical marijuana to provide overall synergy, as well as balance. CBG acts as a stepping stone or building block in the development of most …

Although cannabidiol (CBD) is commonly thought of as being non-psychoactive, researchers have now demonstrated that CBD exhibits antipsychotic, anxiolytic (anxiety-reducing) and antidepressant effects. Therefore, CBD is technically “psychoactive” because it does affect the mind. The more appropriate answer is CBD is “not psychoactive like THC.” Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …

When THC is exposed to air it oxidizes and forms Cannabinol (CBN). CBN has very little psychoactive effects and interacts with THC to reduce its effects. This is why cannabis that has been left out over time (exposed to the air), will have increasing amounts of CBN and decreasing amounts of THC, thus losing its potency and stoney effect. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …

Cannabichromene (CBC) is a cannabinoid found in medical marijuana that stems from CBG-A. It has been found to be successful in treating migraines. CBC is known to help minimize pain and inflammation in patients. One of the most intriguing findings about CBC is that it has anti-proliferative effects, meaning it inhibits the growth of some cancerous tumors, resulting from its interaction with anandamide. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; …

No, it does not. Marinol is a synthetic (man-made) version of THC. When the drug was first introduced in the mid-80s, it was thought it would have the same effect as the cannabis plant as a whole. However, it soon became clear that most patients were not responding the same as when THC is consumed by smoking or ingesting cannabis. Researchers soon realized that other key compounds, such as other cannabinoids and terpenes, played a larger role than previously realized. Click here to learn more. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var …

The concept of the “entourage effect” was introduced in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam. The theory is that cannabinoids within the cannabis plant work together through a network of coincidental relationships as part of a greater organism, and affect the body in a mechanism similar to the body’s own endocannabinoid system. Basically, these compounds work better together than in isolation. When delivered in high concentrations, THC can cause overdosing. Although an acute THC overdose rarely requires medical intervention, the side effects can be very unpleasant. Good evidence shows that THC …

New data shows that cannabidiol (CBD) could be helpful in treating diseases linked to endocannabinoid deficits (such as anorexia, migraines, irritable bowel, fibromyalgia, and PTSD), in addition to treating conditions associated with endocannabinoid excess or overactivity (obesity, metabolic disorders, liver disease, cardiovascular issues). Click here to learn more about CBD. Click here to learn more about the different types of cannabinoids found in cannabis. MANTIS_RECOMMEND = { property: '53422cdc8e92f89afbf09d5f', render: 'mantis__recommended__wordpress' }; var z = document.createElement("script"); z.type = "text/javascript"; z.async = true; z.src = "//static.mantis.marketing/recommend.min.js"; var s = document.getElementsByTagName('head')[0]; s.parentNode.insertBefore(z, s); …